Paper Details

Name: Gobind Ram, Ramandeep Kaur
Email: ramgobind4@gmail.com
Country: India

Year: 2015
Volume: Volume-2, Issue-1

Survivin is a member of inhibitor of apoptosis protein family and plays an important role in cell division. This protein is undetectable in normal cells but is highly expressed in variety of human cancers including that of colon, breast, lung, pancreas and stomach that makes it a potential target for cancer treatment. Survivin, 142 amino acid proteins, is encoded by gene located on human chromosome 17 at band q25. It contains a baculovirus inhibitor of apoptosis repeat (BIR) protein domain that consists of 4 α-helices and 3-beta sheets. This BIR domain is essential for anti- apoptotic activity. Apoptosis is programmed cell death which maintains equivalence between the cell division and cell death. Survivin mainly inhibit caspases (cystein dependent aspartate directed proteases) that are involved in apoptosis and thus suppresses the apoptosis. It also acts as a subunit of chromosomal passenger complex that is required for proper chromosomal segregation and cytokinesis. Thus, Survivin plays dual role in spindle monitoring at mitosis and ability to inhibit apoptosis through the inhibition of caspases. In silico analysis was performed for homology search, motif and domain prediction and validation of model to the level of drug designing. Here we choose a ligand from zinc database and its drug properties like drug likeliness, solubility, clogP, drug score etc. were checked by Osiris property explorer and via Mol Inspiration. Docking was performed by using Hex software and Autodock Vina tool.